| Title | [Rasburicase for tophaceus gout treatment.] | | Author(s) | Ribeiro A, Bogas M, Costa J, Costa L, Araújo D | | Institution | Serviço Reumatologia, Unidade Local de Saúde do Alto Minho, Ponte de Lima. | | Source | Acta Reumatol Port 2009 Jul-Sep; 34(3):551-554. | | Abstract | The main obstacle to the treatment of hyperuricemia in patients with allergy to allopurinol is the limited availability of equally efficient alternative drugs. The authors present a clinical case of a patient with incapacitant tophaceus gout, allergy to allopurinol and contraindication for uricosurics, who was treated with rasburicase, an urato-oxidase recombinant, based on experience with this drug in tumoral lisis and in some cases reports of tophaceus gout. The authors also enhance the fact of being a patient with a sequelar hemiplegia of a previous cerebrovascular disease that presents tophus only in the not paretic member. The management of patients with allergy to allopurinol can be a clinical challenge, and the monthly rasburicase perfusions may be an alternative treatment of serious gout not treatable for other ways. | | Language | POR | | Pub Type(s) | JOURNAL ARTICLE
| | PubMed ID | 19820680 |
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